AustralieFrV1, Main, Exploration, bibRecord, 004027

Parental occupational pesticide exposure and the risk of childhood leukemia in the offspring: Findings from the childhood leukemia international consortium

Identifieur interne : 004027 ( Main/Exploration ); précédent : 004026; suivant : 004028

Parental occupational pesticide exposure and the risk of childhood leukemia in the offspring: Findings from the childhood leukemia international consortium

Auteurs : Helen D. Bailey [France] ; Lin Fritschi [Australie] ; Claire Infante-Rivard [Canada] ; Deborah C. Glass [Australie] ; Lucia Miligi [Italie] ; John D. Dockerty [Nouvelle-Zélande] ; Tracy Lightfoot [Royaume-Uni] ; Jacqueline Clavel [France] ; Eve Roman [Royaume-Uni] ; Logan G. Spector [Mongolie] ; Peter Kaatsch [Allemagne] ; Catherine Metayer [États-Unis] ; Corrado Magnani [Italie] ; Elizabeth Milne [Australie] ; Sophia Polychronopoulou [Grèce] ; Jill Simpson [Royaume-Uni] ; Jérémie Rudant [France] ; Vasiliki Sidi [Grèce] ; Roberto Rondelli [Italie] ; Laurent Orsi [France] ; Alice Y. Kang [États-Unis] ; Eleni Petridou [Grèce] ; Joachim Schüz [France]

Source :

International journal of cancer : (Print) [ 0020-7136 ] ; 2014.

RBID : Pascal:14-0228626

Descripteurs français

Pascal (Inist)
- Leucémie, Parent, Exposition professionnelle, Pesticide, Enfant, Descendance, International, Métaanalyse, Cancérologie, Enfance.
Wicri :
- topic : Pesticide, Enfant.

English descriptors

KwdEn :
- Cancerology, Child, International, Leukemia, Metaanalysis, Occupational exposure, Parent, Pesticides, Progeny.

Abstract

Maternal occupational pesticide exposure during pregnancy and/or paternal occupational pesticide exposure around conception have been suggested to increase risk of leukemia in the offspring. With a view to providing insight in this area we pooled individual level data from 13 case-control studies participating in the Childhood Leukemia International Consortium (CLIC). Occupational data were harmonized to a compatible format. Pooled individual analyses were undertaken using unconditional logistic regression. Using exposure data from mothers of 8,236 cases, and 14,850 controls, and from fathers of 8,169 cases and 14,201 controls the odds ratio (OR) for maternal exposure during pregnancy and the risk of acute lymphoblastic leukemia (ALL) was 1.01 [95% confidence interval (CI) 0.78, 1.30] and for paternal exposure around conception 1.20 (95% 1.06, 1.38). For acute myeloid leukemia (AML), the OR for maternal exposure during pregnancy was 1.94 (CI 1.19, 3.18) and for paternal exposure around conception 0.91 (CI 0.66, 1.24.) based on data from 1,329 case and 12,141 control mothers, and 1,231 case and 11,383 control fathers. Our finding of a significantly increased risk of AML in the offspring with maternal exposure to pesticides during pregnancy is consistent with previous reports. We also found a slight increase in risk of ALL with paternal exposure around conception which appeared to be more evident in children diagnosed at the age of 5 years or more and those with T cell ALL which raises interesting questions on possible mechanisms.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845098

Affiliations:

Allemagne, Australie, Canada, France, Grèce, Italie, Mongolie, Nouvelle-Zélande, Royaume-Uni, États-Unis
Attique (région), Auvergne-Rhône-Alpes, Québec, Rhénanie-Palatinat, Rhône-Alpes, Victoria (État), Île-de-France
Athènes, Lyon, Mayence, Melbourne, Montréal, Orsay, Paris
Université McGill, Université Paris-Sud

Le document en format XML

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<sZ>9 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>York</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Clavel, Jacqueline" sort="Clavel, Jacqueline" uniqKey="Clavel J" first="Jacqueline" last="Clavel">Jacqueline Clavel</name>
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<s3>FRA</s3>
<sZ>8 aut.</sZ>
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<sZ>20 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
<settlement type="city">Orsay</settlement>
</placeName>
<orgName type="university">Université Paris-Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Roman, Eve" sort="Roman, Eve" uniqKey="Roman E" first="Eve" last="Roman">Eve Roman</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Health Sciences, University of York</s1>
<s2>York</s2>
<s3>GBR</s3>
<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>York</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Spector, Logan G" sort="Spector, Logan G" uniqKey="Spector L" first="Logan G." last="Spector">Logan G. Spector</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Division of Epidemiology Clinical Research, Department of Pediatrics and Masonic Cancer Center, University of Minnesota</s1>
<s2>Minneapolis</s2>
<s3>MNG</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Mongolie</country>
<wicri:noRegion>Minneapolis</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kaatsch, Peter" sort="Kaatsch, Peter" uniqKey="Kaatsch P" first="Peter" last="Kaatsch">Peter Kaatsch</name>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>German Childhood Cancer Registry (GCCR) at the Institute for Medical Biostatistics, Epidemiology and Informatics, University Medical Centre, Johannes Gutenberg University Mainz</s1>
<s2>Mainz</s2>
<s3>DEU</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="2">Rhénanie-Palatinat</region>
<settlement type="city">Mayence</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Metayer, Catherine" sort="Metayer, Catherine" uniqKey="Metayer C" first="Catherine" last="Metayer">Catherine Metayer</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>University of California, Berkeley, School of Public Health</s1>
<s2>Berkeley, CA</s2>
<s3>USA</s3>
<sZ>12 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
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</author>
<author><name sortKey="Magnani, Corrado" sort="Magnani, Corrado" uniqKey="Magnani C" first="Corrado" last="Magnani">Corrado Magnani</name>
<affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Dipartimento di Medicina Traslazionale-Università del Piemonte Orientale, AOU Maggiore della Carità e CPO-Piemonte</s1>
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<s3>ITA</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Italie</country>
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</author>
<author><name sortKey="Milne, Elizabeth" sort="Milne, Elizabeth" uniqKey="Milne E" first="Elizabeth" last="Milne">Elizabeth Milne</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Telethon Kids Institute, the University of Western Australia</s1>
<s2>Perth</s2>
<s3>AUS</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Perth</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Polychronopoulou, Sophia" sort="Polychronopoulou, Sophia" uniqKey="Polychronopoulou S" first="Sophia" last="Polychronopoulou">Sophia Polychronopoulou</name>
<affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Department of Pediatric Hematology-Oncology, Athens University Medical School, "Aghia Sophia" General Children's Hospital</s1>
<s2>Athens</s2>
<s3>GRC</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Grèce</country>
<placeName><settlement type="city">Athènes</settlement>
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</affiliation>
</author>
<author><name sortKey="Simpson, Jill" sort="Simpson, Jill" uniqKey="Simpson J" first="Jill" last="Simpson">Jill Simpson</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Health Sciences, University of York</s1>
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<sZ>7 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>16 aut.</sZ>
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<country>Royaume-Uni</country>
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</author>
<author><name sortKey="Rudant, Jeremie" sort="Rudant, Jeremie" uniqKey="Rudant J" first="Jérémie" last="Rudant">Jérémie Rudant</name>
<affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Inserm, CESP Centre for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer Team, Université Paris-Sud</s1>
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<s3>FRA</s3>
<sZ>8 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
<settlement type="city">Orsay</settlement>
</placeName>
<orgName type="university">Université Paris-Sud</orgName>
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</author>
<author><name sortKey="Sidi, Vasiliki" sort="Sidi, Vasiliki" uniqKey="Sidi V" first="Vasiliki" last="Sidi">Vasiliki Sidi</name>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Department of Pediatric Hematology-Oncology, Ippokrateion Hospital</s1>
<s2>Salonica</s2>
<s3>GRC</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Grèce</country>
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</affiliation>
</author>
<author><name sortKey="Rondelli, Roberto" sort="Rondelli, Roberto" uniqKey="Rondelli R" first="Roberto" last="Rondelli">Roberto Rondelli</name>
<affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Department of Paediatric Haematology-Oncology, Lalla Seràgnoli, Policlinico Sant'Orsola Malpighi</s1>
<s2>Bologna</s2>
<s3>ITA</s3>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>Italie</country>
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</affiliation>
</author>
<author><name sortKey="Orsi, Laurent" sort="Orsi, Laurent" uniqKey="Orsi L" first="Laurent" last="Orsi">Laurent Orsi</name>
<affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Inserm, CESP Centre for Research in Epidemiology and Population Health, Environmental Epidemiology of Cancer Team, Université Paris-Sud</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>8 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
<settlement type="city">Orsay</settlement>
</placeName>
<orgName type="university">Université Paris-Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Kang, Alice Y" sort="Kang, Alice Y" uniqKey="Kang A" first="Alice Y." last="Kang">Alice Y. Kang</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>University of California, Berkeley, School of Public Health</s1>
<s2>Berkeley, CA</s2>
<s3>USA</s3>
<sZ>12 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Berkeley, CA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Petridou, Eleni" sort="Petridou, Eleni" uniqKey="Petridou E" first="Eleni" last="Petridou">Eleni Petridou</name>
<affiliation wicri:level="3"><inist:fA14 i1="17"><s1>Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Medical School</s1>
<s2>Athens</s2>
<s3>GRC</s3>
<sZ>22 aut.</sZ>
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<country>Grèce</country>
<placeName><settlement type="city">Athènes</settlement>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Schuz, Joachim" sort="Schuz, Joachim" uniqKey="Schuz J" first="Joachim" last="Schüz">Joachim Schüz</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>International Agency for Research on Cancer (IARC), Section of Environment and Radiation, 150 Cours Albert Thomas</s1>
<s2>Lyon</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">International journal of cancer : (Print)</title>
<title level="j" type="abbreviated">Int. j. cancer : (Print)</title>
<idno type="ISSN">0020-7136</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">International journal of cancer : (Print)</title>
<title level="j" type="abbreviated">Int. j. cancer : (Print)</title>
<idno type="ISSN">0020-7136</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cancerology</term>
<term>Child</term>
<term>International</term>
<term>Leukemia</term>
<term>Metaanalysis</term>
<term>Occupational exposure</term>
<term>Parent</term>
<term>Pesticides</term>
<term>Progeny</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Leucémie</term>
<term>Parent</term>
<term>Exposition professionnelle</term>
<term>Pesticide</term>
<term>Enfant</term>
<term>Descendance</term>
<term>International</term>
<term>Métaanalyse</term>
<term>Cancérologie</term>
<term>Enfance</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Pesticide</term>
<term>Enfant</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Maternal occupational pesticide exposure during pregnancy and/or paternal occupational pesticide exposure around conception have been suggested to increase risk of leukemia in the offspring. With a view to providing insight in this area we pooled individual level data from 13 case-control studies participating in the Childhood Leukemia International Consortium (CLIC). Occupational data were harmonized to a compatible format. Pooled individual analyses were undertaken using unconditional logistic regression. Using exposure data from mothers of 8,236 cases, and 14,850 controls, and from fathers of 8,169 cases and 14,201 controls the odds ratio (OR) for maternal exposure during pregnancy and the risk of acute lymphoblastic leukemia (ALL) was 1.01 [95% confidence interval (CI) 0.78, 1.30] and for paternal exposure around conception 1.20 (95% 1.06, 1.38). For acute myeloid leukemia (AML), the OR for maternal exposure during pregnancy was 1.94 (CI 1.19, 3.18) and for paternal exposure around conception 0.91 (CI 0.66, 1.24.) based on data from 1,329 case and 12,141 control mothers, and 1,231 case and 11,383 control fathers. Our finding of a significantly increased risk of AML in the offspring with maternal exposure to pesticides during pregnancy is consistent with previous reports. We also found a slight increase in risk of ALL with paternal exposure around conception which appeared to be more evident in children diagnosed at the age of 5 years or more and those with T cell ALL which raises interesting questions on possible mechanisms.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Canada</li>
<li>France</li>
<li>Grèce</li>
<li>Italie</li>
<li>Mongolie</li>
<li>Nouvelle-Zélande</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Attique (région)</li>
<li>Auvergne-Rhône-Alpes</li>
<li>Québec</li>
<li>Rhénanie-Palatinat</li>
<li>Rhône-Alpes</li>
<li>Victoria (État)</li>
<li>Île-de-France</li>
</region>
<settlement><li>Athènes</li>
<li>Lyon</li>
<li>Mayence</li>
<li>Melbourne</li>
<li>Montréal</li>
<li>Orsay</li>
<li>Paris</li>
</settlement>
<orgName><li>Université McGill</li>
<li>Université Paris-Sud</li>
</orgName>
</list>
<tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Bailey, Helen D" sort="Bailey, Helen D" uniqKey="Bailey H" first="Helen D." last="Bailey">Helen D. Bailey</name>
</region>
<name sortKey="Clavel, Jacqueline" sort="Clavel, Jacqueline" uniqKey="Clavel J" first="Jacqueline" last="Clavel">Jacqueline Clavel</name>
<name sortKey="Orsi, Laurent" sort="Orsi, Laurent" uniqKey="Orsi L" first="Laurent" last="Orsi">Laurent Orsi</name>
<name sortKey="Rudant, Jeremie" sort="Rudant, Jeremie" uniqKey="Rudant J" first="Jérémie" last="Rudant">Jérémie Rudant</name>
<name sortKey="Schuz, Joachim" sort="Schuz, Joachim" uniqKey="Schuz J" first="Joachim" last="Schüz">Joachim Schüz</name>
</country>
<country name="Australie"><noRegion><name sortKey="Fritschi, Lin" sort="Fritschi, Lin" uniqKey="Fritschi L" first="Lin" last="Fritschi">Lin Fritschi</name>
</noRegion>
<name sortKey="Glass, Deborah C" sort="Glass, Deborah C" uniqKey="Glass D" first="Deborah C." last="Glass">Deborah C. Glass</name>
<name sortKey="Milne, Elizabeth" sort="Milne, Elizabeth" uniqKey="Milne E" first="Elizabeth" last="Milne">Elizabeth Milne</name>
</country>
<country name="Canada"><region name="Québec"><name sortKey="Infante Rivard, Claire" sort="Infante Rivard, Claire" uniqKey="Infante Rivard C" first="Claire" last="Infante-Rivard">Claire Infante-Rivard</name>
</region>
</country>
<country name="Italie"><noRegion><name sortKey="Miligi, Lucia" sort="Miligi, Lucia" uniqKey="Miligi L" first="Lucia" last="Miligi">Lucia Miligi</name>
</noRegion>
<name sortKey="Magnani, Corrado" sort="Magnani, Corrado" uniqKey="Magnani C" first="Corrado" last="Magnani">Corrado Magnani</name>
<name sortKey="Rondelli, Roberto" sort="Rondelli, Roberto" uniqKey="Rondelli R" first="Roberto" last="Rondelli">Roberto Rondelli</name>
</country>
<country name="Nouvelle-Zélande"><noRegion><name sortKey="Dockerty, John D" sort="Dockerty, John D" uniqKey="Dockerty J" first="John D." last="Dockerty">John D. Dockerty</name>
</noRegion>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Lightfoot, Tracy" sort="Lightfoot, Tracy" uniqKey="Lightfoot T" first="Tracy" last="Lightfoot">Tracy Lightfoot</name>
</noRegion>
<name sortKey="Roman, Eve" sort="Roman, Eve" uniqKey="Roman E" first="Eve" last="Roman">Eve Roman</name>
<name sortKey="Simpson, Jill" sort="Simpson, Jill" uniqKey="Simpson J" first="Jill" last="Simpson">Jill Simpson</name>
</country>
<country name="Mongolie"><noRegion><name sortKey="Spector, Logan G" sort="Spector, Logan G" uniqKey="Spector L" first="Logan G." last="Spector">Logan G. Spector</name>
</noRegion>
</country>
<country name="Allemagne"><region name="Rhénanie-Palatinat"><name sortKey="Kaatsch, Peter" sort="Kaatsch, Peter" uniqKey="Kaatsch P" first="Peter" last="Kaatsch">Peter Kaatsch</name>
</region>
</country>
<country name="États-Unis"><noRegion><name sortKey="Metayer, Catherine" sort="Metayer, Catherine" uniqKey="Metayer C" first="Catherine" last="Metayer">Catherine Metayer</name>
</noRegion>
<name sortKey="Kang, Alice Y" sort="Kang, Alice Y" uniqKey="Kang A" first="Alice Y." last="Kang">Alice Y. Kang</name>
</country>
<country name="Grèce"><region name="Attique (région)"><name sortKey="Polychronopoulou, Sophia" sort="Polychronopoulou, Sophia" uniqKey="Polychronopoulou S" first="Sophia" last="Polychronopoulou">Sophia Polychronopoulou</name>
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<name sortKey="Petridou, Eleni" sort="Petridou, Eleni" uniqKey="Petridou E" first="Eleni" last="Petridou">Eleni Petridou</name>
<name sortKey="Sidi, Vasiliki" sort="Sidi, Vasiliki" uniqKey="Sidi V" first="Vasiliki" last="Sidi">Vasiliki Sidi</name>
</country>
</tree>
</affiliations>
</record>

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Serveur d'exploration sur les relations entre la France et l'Australie

Parental occupational pesticide exposure and the risk of childhood leukemia in the offspring: Findings from the childhood leukemia international consortium

Parental occupational pesticide exposure and the risk of childhood leukemia in the offspring: Findings from the childhood leukemia international consortium

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